ARO Term	ARO Accession	Reference Model Type	Reference DB	Alleles with Mapped Reads	Reference Allele(s) Identity to CARD Reference Protein (%)	Resistomes & Variants: Observed in Genome(s)	Resistomes & Variants: Observed in Plasmid(s)	Resistomes & Variants: Observed Pathogen(s)	Completely Mapped Reads	Mapped Reads with Flanking Sequence	All Mapped Reads	Average Percent Coverage	Average Length Coverage (bp)	Average MAPQ (Completely Mapped Reads)	Number of Mapped Baits	Number of Mapped Baits with Reads	Average Number of reads per Bait	Number of reads per Bait Coefficient of Variation (%)	Number of reads mapping to baits and mapping to complete gene	Number of reads mapping to baits and mapping to complete gene (%)	Mate Pair Linkage (# reads)	Reference Length	AMR Gene Family	Drug Class	Resistance Mechanism
dfrF	3002867	protein homolog model	CARD; Resistomes & Variants	2	99.39 - 100.0	no data	no data	Enterococcus faecalis; Enterococcus faecium	23.00	0.00	23.00	72.02	356.50	158.12	0	0	0	0	N/A	N/A		495; 495	trimethoprim resistant dihydrofolate reductase dfr	diaminopyrimidine antibiotic	antibiotic target replacement
CMY-85	3002098	protein homolog model	CARD	1	100.0	no data	no data	Citrobacter freundii	2.00	0.00	2.00	26.27	301.00	200.50	0	0	0	0	N/A	N/A		1146	CMY beta-lactamase	cephamycin	antibiotic inactivation
tet(W)	3000194	protein homolog model	CARD; Resistomes & Variants	27	95.85 - 100.0	YES	no data	Butyrivibrio fibrisolvens; Bifidobacterium animalis; Bifidobacterium bifidum; Bifidobacterium breve; Bifidobacterium longum; Eggerthella lenta; Collinsella aerofaciens; Faecalibacterium prausnitzii; Lactobacillus johnsonii; Enterocloster clostridioformis; Streptococcus suis	872.00	0.00	872.00	24.32	466.41	197.32	0	0	0	0	N/A	N/A		1920; 1920; 1920; 1920; 2082; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1920; 1590; 1920; 1920	tetracycline-resistant ribosomal protection protein	tetracycline antibiotic	antibiotic target protection
emeA	3003551	protein homolog model	CARD	1	100.0	no data	no data	Enterococcus faecalis	1.00	0.00	1.00	12.77	151.00	201.00	0	0	0	0	N/A	N/A		1182	multidrug and toxic compound extrusion (MATE) transporter	disinfecting agents and antiseptics	antibiotic efflux
vanD	3000005	protein homolog model	CARD; Resistomes & Variants	5	84.55 - 100.0	YES	no data	Enterococcus faecium; Blautia producta; Enterocloster clostridioformis	57.00	0.00	57.00	55.82	564.40	196.73	0	0	0	0	N/A	N/A		1032; 1032; 1032; 744; 1032	glycopeptide resistance gene cluster; Van ligase	glycopeptide antibiotic	antibiotic target alteration
sul2	3000412	protein homolog model	CARD; Resistomes & Variants	9	99.26 - 100.0	YES	YES	Vibrio cholerae; Actinobacillus pleuropneumoniae; Bacteroides thetaiotaomicron; Glaesserella parasuis; Pasteurella multocida; Bacteroides ovatus; Escherichia coli; Escherichia fergusonii; Klebsiella pneumoniae	848.00	0.00	848.00	37.54	321.78	192.54	0	0	0	0	N/A	N/A		816; 915; 852; 870; 816; 816; 816; 849; 816	sulfonamide resistant sul	sulfonamide antibiotic	antibiotic target replacement
vanB	3000013	protein homolog model	CARD	1	100.0	no data	no data	Enterococcus faecium	2.00	0.00	2.00	29.15	300.00	199.50	0	0	0	0	N/A	N/A		1029	glycopeptide resistance gene cluster; Van ligase	glycopeptide antibiotic	antibiotic target alteration
vanR gene in vanD cluster	3002923	protein homolog model	CARD; Resistomes & Variants	8	90.09 - 100.0	YES	no data	Enterococcus faecium; Blautia producta; Enterocloster clostridioformis; Enterococcus faecalis; Ruthenibacterium lactatiformans	47.00	0.00	47.00	47.96	334.88	178.85	0	0	0	0	N/A	N/A		699; 699; 699; 696; 699; 699; 699; 699	glycopeptide resistance gene cluster; vanR	glycopeptide antibiotic	antibiotic target alteration
mel	3000616	protein homolog model	CARD	1	100.0	no data	no data	Streptococcus pyogenes	154.00	0.00	154.00	100.00	1218.00	181.86	0	0	0	0	N/A	N/A		1218	msr-type ABC-F protein	macrolide antibiotic; streptogramin antibiotic	antibiotic target protection
tet(44)	3000556	protein homolog model	CARD; Resistomes & Variants	2	98.44 - 100.0	no data	no data	Campylobacter fetus; Clostridium perfringens	4.00	0.00	4.00	14.28	274.50	200.25	0	0	0	0	N/A	N/A		1923; 1923	tetracycline-resistant ribosomal protection protein	tetracycline antibiotic	antibiotic target protection
tet(Q)	3000191	protein homolog model	CARD; Resistomes & Variants	83	90.48 - 100.0	YES	no data	Bacteroides fragilis; Alistipes putredinis; Bacteroides caccae; Bacteroides ovatus; Phocaeicola vulgatus; Bacteroides thetaiotaomicron; Butyricimonas faecalis; Parabacteroides distasonis; Phocaeicola dorei; Phocaeicola massiliensis; Porphyromonas gingivalis; Prevotella bivia; Prevotella intermedia; Riemerella anatipestifer; Eubacterium maltosivorans; Muribaculaceae bacterium	41863.00	0.00	41863.00	21.25	331.87	194.79	0	0	0	0	N/A	N/A		1974; 1974; 1974; 1974; 1926; 1995; 1974; 1926; 1926; 1974; 1974; 1665; 1974; 1974; 1974; 1947; 516; 1926; 1926; 528; 1926; 1974; 1947; 1926; 1275; 1926; 1926; 1791; 1926; 1623; 1098; 1926; 1926; 1542; 1020; 1926; 696; 1995; 1926; 1926; 1515; 1926; 1974; 1356; 1974; 1995; 948; 1137; 1926; 1344; 1947; 912; 1947; 1926; 1176; 861; 1644; 1005; 1974; 1791; 861; 1074; 1926; 1662; 1668; 1851; 1770; 1947; 1152; 1917; 1947; 1611; 1920; 1926; 1302; 1581; 1926; 573; 801; 1302; 1113; 1974; 1995	tetracycline-resistant ribosomal protection protein	tetracycline antibiotic	antibiotic target protection
tet(32)	3000196	protein homolog model	CARD; Resistomes & Variants	3	75.9 - 100.0	YES	no data	Escherichia coli; Campylobacter concisus; Enterococcus faecalis; Erysipelatoclostridium ramosum; Eubacterium limosum; Faecalibacterium prausnitzii; Roseburia hominis; Ruthenibacterium lactatiformans; Streptococcus anginosus; Streptococcus constellatus; Streptococcus intermedius; Streptococcus pneumoniae; Enterocloster clostridioformis	108.00	0.00	108.00	63.60	1221.00	198.07	0	0	0	0	N/A	N/A		1920; 1920; 1920	tetracycline-resistant ribosomal protection protein	tetracycline antibiotic	antibiotic target protection
APH(3')-IIIa	3002647	protein homolog model	CARD; Resistomes & Variants	2	100.0	no data	no data	Campylobacter coli; Streptococcus suis	229.00	0.00	229.00	74.35	594.00	190.50	0	0	0	0	N/A	N/A		795; 807	APH(3')	aminoglycoside antibiotic	antibiotic inactivation
ACC-3	3001817	protein homolog model	CARD	1	100.0	no data	no data	Hafnia alvei	58.00	0.00	58.00	100.00	1131.00	195.38	0	0	0	0	N/A	N/A		1131	ACC beta-lactamase	monobactam; cephalosporin; penam	antibiotic inactivation
vanX gene in vanD cluster	3003070	protein homolog model	CARD; Resistomes & Variants	2	87.62 - 100.0	no data	no data	Enterococcus faecium; Blautia producta	31.00	0.00	31.00	100.00	609.00	192.26	0	0	0	0	N/A	N/A		609; 609	vanX; glycopeptide resistance gene cluster	glycopeptide antibiotic	antibiotic target alteration
vanS gene in vanD cluster	3002934	protein homolog model	CARD	1	100.0	no data	no data	Enterococcus faecium	29.00	0.00	29.00	100.00	702.00	160.59	0	0	0	0	N/A	N/A		702	vanS; glycopeptide resistance gene cluster	glycopeptide antibiotic	antibiotic target alteration
Klebsiella pneumoniae acrA	3004041	protein homolog model	CARD	1	100.0	no data	no data	Klebsiella pneumoniae	5.00	0.00	5.00	29.82	357.00	156.80	0	0	0	0	N/A	N/A		1197	resistance-nodulation-cell division (RND) antibiotic efflux pump	fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics	antibiotic efflux
tet(W/N/W)	3004442	protein homolog model	CARD; Resistomes & Variants	2	94.2 - 100.0	no data	no data	uncultured bacterium; Bifidobacterium breve	20.00	0.00	20.00	22.61	434.00	193.59	0	0	0	0	N/A	N/A		1920; 1920	tetracycline-resistant ribosomal protection protein	tetracycline antibiotic	antibiotic target protection
tet(O/32/O)	3007119	protein homolog model	CARD	1	100.0	no data	no data	Clostridiaceae bacterium	32.00	0.00	32.00	42.76	821.00	200.62	0	0	0	0	N/A	N/A		1920	tetracycline-resistant ribosomal protection protein	tetracycline antibiotic	antibiotic target protection
tet(W/32/O)	3007124	protein homolog model	CARD; Resistomes & Variants	2	93.42 - 100.0	no data	no data	Trueperella pyogenes; Dysosmobacter welbionis	102.00	0.00	102.00	24.74	475.00	191.73	0	0	0	0	N/A	N/A		1920; 1920	tetracycline-resistant ribosomal protection protein	tetracycline antibiotic	antibiotic target protection
tet(O)	3000190	protein homolog model	Resistomes & Variants	47	92.96 - 100.0	YES	NO	Actinobacillus pleuropneumoniae; Streptococcus agalactiae; Streptococcus suis; Anaerostipes hadrus; Campylobacter concisus; Corynebacterium amycolatum; Corynebacterium diphtheriae; Eggerthella lenta; Enterococcus faecalis; Enterococcus faecium; Enterococcus hirae; Eubacterium limosum; Eubacterium maltosivorans; Staphylococcus pseudintermedius; Streptococcus pasteurianus; Streptococcus canis; Streptococcus dysgalactiae; Streptococcus equi; Streptococcus gallolyticus; Streptococcus iniae; Streptococcus pneumoniae; Streptococcus porcinus; Streptococcus pyogenes; Streptococcus uberis; Campylobacter jejuni; Bifidobacterium bifidum; Campylobacter coli; Bifidobacterium breve; Enterocloster clostridioformis; Erysipelatoclostridium ramosum; Ruthenibacterium lactatiformans; Streptococcus anginosus; Streptococcus constellatus; Streptococcus gordonii; Faecalibacterium prausnitzii	1842.00	0.00	1842.00	23.83	420.13	195.35	0	0	0	0	N/A	N/A		1920; 1920; 1920; 1065; 1920; 1746; 1044; 1920; 1920; 1851; 1041; 1362; 1920; 600; 1248; 1920; 777; 1920; 1920; 1920; 1785; 930; 1920; 1920; 1920; 1746; 1920; 1920; 1920; 1920; 1920; 1920; 1767; 1920; 1920; 1920; 1920; 672; 1920; 1920; 1806; 2007; 1920; 1932; 1920; 1209; 1920	tetracycline-resistant ribosomal protection protein	tetracycline antibiotic	antibiotic target protection
vanG	3002909	protein homolog model	Resistomes & Variants	9	37.95 - 41.38	YES	NO	Anaerostipes hadrus; Escherichia coli; Klebsiella oxytoca	434.00	0.00	434.00	42.84	464.67	194.05	0	0	0	0	N/A	N/A		1062; 1062; 1062; 1104; 1095; 1152; 1095; 1098; 1131	glycopeptide resistance gene cluster; Van ligase	glycopeptide antibiotic	antibiotic target alteration
tet(40)	3000567	protein homolog model	Resistomes & Variants	7	96.8 - 98.77	YES	NO	Anaerostipes hadrus; Enterococcus faecium; Fusobacterium necrophorum; Streptococcus equi; Streptococcus suis; Roseburia hominis; Faecalibacterium prausnitzii; Clostridioides difficile; Enterocloster clostridioformis	292.00	0.00	292.00	47.09	577.43	185.26	0	0	0	0	N/A	N/A		1221; 1254; 1239; 1221; 1221; 1221; 1221	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux
APH(3'')-Ib	3002639	protein homolog model	Resistomes & Variants	10	98.88 - 99.62	NO	YES	Acinetobacter indicus; Citrobacter freundii; Escherichia coli; Klebsiella pneumoniae; Salmonella enterica	312.00	0.00	312.00	33.00	277.50	199.38	0	0	0	0	N/A	N/A		807; 990; 804; 864; 804; 933; 804; 798; 804; 801	APH(3'')	aminoglycoside antibiotic	antibiotic inactivation
aad(6)	3002628	protein homolog model	Resistomes & Variants	1	100.0	YES	YES	Aliarcobacter butzleri; Bacteroides fragilis; Bacteroides thetaiotaomicron; Bifidobacterium breve; Campylobacter coli; Campylobacter jejuni; Enterocloster clostridioformis; Enterococcus avium; Enterococcus faecalis; Enterococcus faecium; Staphylococcus aureus; Staphylococcus epidermidis; Enterococcus hirae; Eubacterium limosum; Listeria monocytogenes; Parabacteroides distasonis; Phocaeicola vulgatus; Streptococcus suis; Staphylococcus hominis; Staphylococcus pseudintermedius; Staphylococcus saprophyticus; Staphylococcus warneri; Streptococcus agalactiae; Streptococcus anginosus; Streptococcus equi; Streptococcus gallolyticus; Streptococcus mutans; Streptococcus pasteurianus; Streptococcus pyogenes	76.00	0.00	76.00	100.00	909.00	199.22	0	0	0	0	N/A	N/A		909	ANT(6)	aminoglycoside antibiotic	antibiotic inactivation
APH(6)-Id	3002660	protein homolog model	Resistomes & Variants	20	98.15 - 99.64	YES	YES	Acinetobacter baumannii; Acinetobacter pittii; Escherichia coli; Histophilus somni; Pasteurella multocida; Enterobacter hormaechei; Escherichia fergusonii; Klebsiella michiganensis; Klebsiella pneumoniae; Klebsiella quasipneumoniae; Salmonella enterica; Shigella sonnei	1541.00	0.00	1541.00	34.20	370.40	199.02	0	0	0	0	N/A	N/A		837; 864; 837; 915; 837; 846; 882; 837; 855; 1641; 837; 891; 837; 837; 909; 1011; 1257; 960; 1638; 942	APH(6)	aminoglycoside antibiotic	antibiotic inactivation
SAT-4	3002897	protein homolog model	Resistomes & Variants	3	98.89 - 99.44	NO	NO	Campylobacter jejuni; Enterococcus faecium; Staphylococcus epidermidis	51.00	0.00	51.00	62.87	358.00	167.81	0	0	0	0	N/A	N/A		573; 543; 579	streptothricin acetyltransferase (SAT)	nucleoside antibiotic	antibiotic inactivation
adeF	3000777	protein homolog model	Resistomes & Variants	23	41.28 - 61.05	YES	NO	Cronobacter sakazakii; Citrobacter koseri; Cronobacter malonaticus; Bacteroides thetaiotaomicron; Bacteroides fragilis; Yersinia kristensenii; Phocaeicola vulgatus; Klebsiella aerogenes; Klebsiella pneumoniae; Enterobacter roggenkampii; Klebsiella oxytoca; Klebsiella quasipneumoniae; Leclercia adecarboxylata; Edwardsiella tarda; Yersinia enterocolitica	136.00	0.00	136.00	17.11	537.48	159.09	0	0	0	0	N/A	N/A		3117; 3147; 3150; 3105; 3258; 3105; 3105; 3180; 3153; 3117; 3090; 3147; 3147; 3147; 3336; 3147; 3114; 3153; 3147; 3147; 3114; 3153; 3153	resistance-nodulation-cell division (RND) antibiotic efflux pump	fluoroquinolone antibiotic; tetracycline antibiotic	antibiotic efflux
mdtG	3001329	protein homolog model	Resistomes & Variants	21	89.68 - 100.0	YES	NO	Citrobacter koseri; Citrobacter amalonaticus; Escherichia coli; Shigella dysenteriae; Salmonella enterica	1053.00	0.00	1053.00	22.42	274.62	181.39	0	0	0	0	N/A	N/A		1221; 1221; 1221; 1227; 1227; 1227; 1227; 1227; 1227; 1158; 1227; 1227; 1227; 1227; 1227; 1281; 1275; 1227; 1227; 1227; 1215	major facilitator superfamily (MFS) antibiotic efflux pump	phosphonic acid antibiotic	antibiotic efflux
mdtC	3000794	protein homolog model	Resistomes & Variants	23	92.39 - 99.71	YES	NO	Citrobacter koseri; Citrobacter freundii; Citrobacter amalonaticus; Enterobacter cloacae; Escherichia coli; Enterobacter hormaechei; Enterobacter cancerogenus	2513.00	0.00	2513.00	16.67	533.96	181.21	0	0	0	0	N/A	N/A		3087; 4491; 3081; 3081; 3072; 3081; 3078; 3078; 3078; 3078; 3078; 3078; 6201; 3078; 3078; 3078; 2988; 3078; 3078; 3078; 3078; 3078; 3078	resistance-nodulation-cell division (RND) antibiotic efflux pump	aminocoumarin antibiotic	antibiotic efflux
tet(X)	3000205	protein homolog model	Resistomes & Variants	5	99.23 - 99.74	NO	YES	Bacteroides fragilis; Phocaeicola vulgatus; Bacteroides ovatus; Bacteroides thetaiotaomicron; Elizabethkingia anophelis; Parabacteroides distasonis; Phocaeicola dorei; Phocaeicola massiliensis; Sphingobacterium hotanense; Riemerella anatipestifer	7383.00	0.00	7383.00	44.00	510.00	197.63	0	0	0	0	N/A	N/A		1167; 1137; 1167; 1167; 1167	tetracycline inactivation enzyme	glycylcycline; tetracycline antibiotic	antibiotic inactivation
vanT gene in vanG cluster	3002972	protein homolog model	Resistomes & Variants	2	34.15 - 35.33	YES	NO	Bacteroides thetaiotaomicron; Phocaeicola vulgatus	5.00	0.00	5.00	11.18	282.50	200.38	0	0	0	0	N/A	N/A		2550; 2466	glycopeptide resistance gene cluster; vanT	glycopeptide antibiotic	antibiotic target alteration
ErmF	3000498	protein homolog model	Resistomes & Variants	9	98.12 - 99.62	NO	NO	Bacteroides thetaiotaomicron; Bacteroides fragilis; Parabacteroides distasonis; Phocaeicola vulgatus; Phocaeicola dorei	6994.00	0.00	6994.00	36.50	310.11	165.67	0	0	0	0	N/A	N/A		921; 840; 876; 801; 867; 801; 834; 858; 795	Erm 23S ribosomal RNA methyltransferase	macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic	antibiotic target alteration
ErmG	3000522	protein homolog model	Resistomes & Variants	1	99.52	NO	NO	Bacteroides thetaiotaomicron	2.00	0.00	2.00	47.55	301.00	200.50	0	0	0	0	N/A	N/A		633	Erm 23S ribosomal RNA methyltransferase	macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic	antibiotic target alteration
mdtB	3000793	protein homolog model	Resistomes & Variants	16	92.88 - 99.81	YES	NO	Citrobacter freundii; Citrobacter amalonaticus; Escherichia coli; Shigella sonnei	1566.00	0.00	1566.00	19.71	619.88	190.95	0	0	0	0	N/A	N/A		3123; 3123; 3123; 3123; 3123; 3123; 3123; 4371; 3072; 3123; 3123; 3027; 3123; 3123; 3123; 3372	resistance-nodulation-cell division (RND) antibiotic efflux pump	aminocoumarin antibiotic	antibiotic efflux
vanY gene in vanD cluster	3002957	protein homolog model	Resistomes & Variants	2	75.21 - 83.76	NO	NO	Blautia producta; Enterococcus faecium	27.00	0.00	27.00	46.08	493.50	184.85	0	0	0	0	N/A	N/A		1071; 1071	vanY; glycopeptide resistance gene cluster	glycopeptide antibiotic	antibiotic target alteration
vanH gene in vanD cluster	3002944	protein homolog model	Resistomes & Variants	3	81.42 - 99.69	YES	NO	Blautia producta; Enterococcus faecium; Enterococcus faecalis	44.00	0.00	44.00	61.25	595.33	178.12	0	0	0	0	N/A	N/A		972; 972; 972	vanH; glycopeptide resistance gene cluster	glycopeptide antibiotic	antibiotic target alteration
qacG	3007015	protein homolog model	Resistomes & Variants	1	38.89	YES	NO	Burkholderia cenocepacia	127.00	0.00	127.00	28.09	332.00	0.83	0	0	0	0	N/A	N/A		1182	small multidrug resistance (SMR) antibiotic efflux pump	disinfecting agents and antiseptics	antibiotic efflux
cepA	3003559	protein homolog model	Resistomes & Variants	3	99.67 - 100.0	NO	NO	Bacteroides fragilis	180.00	0.00	180.00	54.13	508.00	189.12	0	0	0	0	N/A	N/A		903; 1011; 963	CepA beta-lactamase	cephalosporin	antibiotic inactivation
Escherichia coli mdfA	3001328	protein homolog model	Resistomes & Variants	12	88.78 - 97.07	YES	NO	Citrobacter amalonaticus; Escherichia coli	752.00	0.00	752.00	26.70	333.42	188.40	0	0	0	0	N/A	N/A		1233; 1233; 1233; 1233; 1233; 1233; 1233; 1233; 1233; 1263; 1437; 1233	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic; disinfecting agents and antiseptics	antibiotic efflux
ErmB	3000375	protein homolog model	Resistomes & Variants	10	97.55 - 98.78	YES	NO	Streptococcus agalactiae; Streptococcus pyogenes; Escherichia coli; Streptococcus suis; Enterococcus faecalis; Staphylococcus aureus	246.00	0.00	246.00	39.48	305.40	186.36	0	0	0	0	N/A	N/A		810; 738; 762; 750; 777; 675; 780; 855; 738; 738	Erm 23S ribosomal RNA methyltransferase	macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic	antibiotic target alteration
AAC(6')-Im	3004629	protein homolog model	Resistomes & Variants	1	100.0	NO	NO	Histophilus somni	2.00	0.00	2.00	49.35	265.00	194.50	0	0	0	0	N/A	N/A		537	AAC(6')	aminoglycoside antibiotic	antibiotic inactivation
Escherichia coli ampC beta-lactamase	3004290	protein homolog model	Resistomes & Variants	5	97.88 - 98.94	YES	NO	Escherichia coli; Shigella boydii; Shigella dysenteriae	29.00	0.00	29.00	23.64	288.40	198.68	0	0	0	0	N/A	N/A		1131; 1134; 1557; 1233; 1134	ampC-type beta-lactamase	cephalosporin; penam	antibiotic inactivation
Klebsiella pneumoniae KpnF	3004583	protein homolog model	Resistomes & Variants	6	83.49 - 84.95	YES	NO	Escherichia coli; Shigella boydii; Shigella flexneri; Shigella sonnei; Shigella dysenteriae	106.00	0.00	106.00	56.22	177.00	196.21	0	0	0	0	N/A	N/A		330; 330; 282; 282; 330; 330	small multidrug resistance (SMR) antibiotic efflux pump	macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics	antibiotic efflux
emrY	3000254	protein homolog model	Resistomes & Variants	15	99.6 - 100.0	YES	NO	Shigella dysenteriae; Escherichia coli; Shigella boydii; Shigella flexneri; Shigella sonnei	1489.00	0.00	1489.00	24.08	370.27	192.75	0	0	0	0	N/A	N/A		1539; 1539; 1539; 1539; 1539; 1539; 1539; 1539; 1539; 1455; 1539; 1539; 1539; 1563; 1539	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux
TolC	3000237	protein homolog model	Resistomes & Variants	13	99.19 - 100.0	YES	NO	Escherichia coli; Shigella dysenteriae; Shigella boydii; Shigella sonnei	766.00	0.00	766.00	25.69	381.23	191.12	0	0	0	0	N/A	N/A		1488; 1482; 1488; 1488; 1482; 1482; 1488; 1482; 1488; 1482; 1488; 1482; 1482	ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics	antibiotic efflux
acrB	3000216	protein homolog model	Resistomes & Variants	32	94.56 - 100.0	YES	NO	Shigella dysenteriae; Escherichia coli; Shigella boydii; Salmonella enterica	1885.00	0.00	1885.00	11.51	363.12	194.26	0	0	0	0	N/A	N/A		3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3150; 3291; 3150	resistance-nodulation-cell division (RND) antibiotic efflux pump	fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics	antibiotic efflux
CfxA2	3003002	protein homolog model	Resistomes & Variants	1	99.38	NO	NO	Phocaeicola vulgatus	8.00	0.00	8.00	65.73	635.00	198.00	0	0	0	0	N/A	N/A		966	CfxA beta-lactamase	cephamycin	antibiotic inactivation
Erm(35)	3000604	protein homolog model	Resistomes & Variants	1	74.44	NO	NO	Phocaeicola vulgatus	1.00	0.00	1.00	18.85	151.00	197.00	0	0	0	0	N/A	N/A		801	Erm 23S ribosomal RNA methyltransferase	macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic	antibiotic target alteration
emrB	3000074	protein homolog model	Resistomes & Variants	18	93.4 - 100.0	YES	NO	Enterobacter asburiae; Escherichia coli; Shigella flexneri; Shigella sonnei; Enterobacter cancerogenus	1239.00	0.00	1239.00	21.08	324.83	193.98	0	0	0	0	N/A	N/A		1548; 1539; 1539; 1539; 1539; 1539; 1539; 1539; 1497; 1539; 1539; 1539; 1539; 1539; 1629; 1539; 1539; 1548	major facilitator superfamily (MFS) antibiotic efflux pump	fluoroquinolone antibiotic	antibiotic efflux
AcrE	3000499	protein homolog model	Resistomes & Variants	17	95.31 - 100.0	YES	NO	Escherichia coli; Shigella flexneri	628.00	0.00	628.00	26.14	303.76	189.56	0	0	0	0	N/A	N/A		1227; 1158; 1185; 1158; 1158; 1158; 1113; 1158; 1158; 1158; 1158; 1158; 1137; 1203; 1158; 1158; 1158	resistance-nodulation-cell division (RND) antibiotic efflux pump	fluoroquinolone antibiotic; cephalosporin; cephamycin; penam	antibiotic efflux
Escherichia coli acrA	3004043	protein homolog model	Resistomes & Variants	14	91.69 - 100.0	YES	NO	Shigella flexneri; Escherichia coli; Salmonella enterica	597.00	0.00	597.00	24.04	286.21	195.78	0	0	0	0	N/A	N/A		1194; 1194; 1194; 1194; 1194; 1194; 1194; 1206; 1212; 1194; 1086; 1194; 1194; 1230	resistance-nodulation-cell division (RND) antibiotic efflux pump	fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics	antibiotic efflux
emrA	3000027	protein homolog model	Resistomes & Variants	12	99.72 - 100.0	YES	NO	Escherichia coli; Shigella flexneri; Shigella sonnei	708.00	0.00	708.00	29.48	344.25	198.82	0	0	0	0	N/A	N/A		1173; 1173; 1173; 1146; 1173; 1173; 1212; 1173; 1173; 1173; 1074; 1101	major facilitator superfamily (MFS) antibiotic efflux pump	fluoroquinolone antibiotic	antibiotic efflux
Klebsiella pneumoniae KpnE	3004580	protein homolog model	Resistomes & Variants	12	79.17 - 86.67	YES	NO	Escherichia coli; Klebsiella oxytoca	190.00	0.00	190.00	44.93	163.83	175.59	0	0	0	0	N/A	N/A		366; 366; 366; 366; 366; 381; 420; 375; 369; 366; 306; 363	small multidrug resistance (SMR) antibiotic efflux pump	macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics	antibiotic efflux
gadW	3003838	protein homolog model	Resistomes & Variants	4	97.11 - 100.0	YES	NO	Escherichia coli	325.00	0.00	325.00	46.47	338.75	196.25	0	0	0	0	N/A	N/A		729; 729; 729; 729	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic; fluoroquinolone antibiotic; penam	antibiotic efflux
evgA	3000832	protein homolog model	Resistomes & Variants	6	99.51 - 100.0	YES	YES	Escherichia coli	303.00	0.00	303.00	51.32	321.83	195.84	0	0	0	0	N/A	N/A		615; 615; 615; 669; 615; 615	major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic	antibiotic efflux
AcrF	3000502	protein homolog model	Resistomes & Variants	20	98.06 - 99.71	YES	NO	Escherichia coli; Shigella boydii; Shigella sonnei	2353.00	0.00	2353.00	16.26	511.20	196.58	0	0	0	0	N/A	N/A		3105; 3105; 3105; 3105; 3105; 3105; 3105; 3105; 3105; 4275; 3105; 3111; 3105; 3105; 3105; 3105; 3105; 3105; 3105; 3105	resistance-nodulation-cell division (RND) antibiotic efflux pump	fluoroquinolone antibiotic; cephalosporin; cephamycin; penam	antibiotic efflux
mdtM	3001214	protein homolog model	Resistomes & Variants	13	93.6 - 98.24	YES	NO	Escherichia coli	902.00	0.00	902.00	26.35	373.23	196.63	0	0	0	0	N/A	N/A		1233; 1260; 1233; 1233; 2553; 1332; 1188; 1239; 1233; 1269; 1281; 2553; 1239	major facilitator superfamily (MFS) antibiotic efflux pump	fluoroquinolone antibiotic; lincosamide antibiotic; nucleoside antibiotic; phenicol antibiotic; disinfecting agents and antiseptics	antibiotic efflux
eptA	3003576	protein homolog model	Resistomes & Variants	4	99.05 - 99.82	YES	NO	Escherichia coli	82.00	0.00	82.00	20.13	327.75	175.52	0	0	0	0	N/A	N/A		1644; 1656; 1644; 1596	pmr phosphoethanolamine transferase	peptide antibiotic	antibiotic target alteration
mdtN	3003548	protein homolog model	Resistomes & Variants	6	99.13 - 100.0	YES	NO	Escherichia coli	780.00	0.00	780.00	44.04	454.50	197.28	0	0	0	0	N/A	N/A		1032; 1032; 1032; 1032; 1032; 1032	major facilitator superfamily (MFS) antibiotic efflux pump	nucleoside antibiotic; disinfecting agents and antiseptics	antibiotic efflux
mdtO	3003549	protein homolog model	Resistomes & Variants	3	97.8 - 98.24	YES	NO	Escherichia coli	34.00	0.00	34.00	13.94	286.00	193.87	0	0	0	0	N/A	N/A		2052; 2052; 2052	major facilitator superfamily (MFS) antibiotic efflux pump	nucleoside antibiotic; disinfecting agents and antiseptics	antibiotic efflux
cpxA	3000830	protein homolog model	Resistomes & Variants	16	96.94 - 100.0	YES	NO	Escherichia coli; Salmonella enterica	894.00	0.00	894.00	21.05	289.25	183.27	0	0	0	0	N/A	N/A		1374; 1374; 1374; 1374; 1374; 1374; 1374; 1374; 1374; 1374; 1374; 1374; 1374; 1374; 1374; 1374	resistance-nodulation-cell division (RND) antibiotic efflux pump	aminoglycoside antibiotic; aminocoumarin antibiotic	antibiotic efflux
mdtA	3000792	protein homolog model	Resistomes & Variants	3	97.32 - 99.04	YES	NO	Escherichia coli	27.00	0.00	27.00	39.11	536.33	191.65	0	0	0	0	N/A	N/A		1248; 1395; 1611	resistance-nodulation-cell division (RND) antibiotic efflux pump	aminocoumarin antibiotic	antibiotic efflux
marA	3000263	protein homolog model	Resistomes & Variants	11	91.13 - 100.0	YES	NO	Escherichia coli; Klebsiella michiganensis; Klebsiella oxytoca; Klebsiella quasipneumoniae	301.00	0.00	301.00	52.87	242.09	184.77	0	0	0	0	N/A	N/A		384; 384; 390; 384; 837; 384; 384; 387; 342; 381; 384	resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams	fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics	antibiotic efflux; reduced permeability to antibiotic
acrD	3000491	protein homolog model	Resistomes & Variants	17	99.61 - 99.9	YES	NO	Escherichia coli	1876.00	0.00	1876.00	15.05	468.53	200.15	0	0	0	0	N/A	N/A		3114; 3114; 3114; 3114; 3114; 3114; 3114; 3114; 3114; 3114; 3114; 3114; 3114; 3114; 3114; 3114; 3114	resistance-nodulation-cell division (RND) antibiotic efflux pump	aminoglycoside antibiotic	antibiotic efflux
emrK	3000206	protein homolog model	Resistomes & Variants	4	96.78 - 98.86	YES	NO	Escherichia coli	42.00	0.00	42.00	24.67	287.25	123.02	0	0	0	0	N/A	N/A		1164; 1176; 1101; 1176	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux
emrR	3000516	protein homolog model	Resistomes & Variants	15	93.14 - 100.0	YES	NO	Escherichia coli; Klebsiella pneumoniae; Salmonella enterica; Klebsiella oxytoca; Klebsiella michiganensis	344.00	0.00	344.00	46.30	250.00	186.72	0	0	0	0	N/A	N/A		531; 531; 432; 468; 501; 531; 531; 531; 531; 660; 639; 486; 540; 531; 654	major facilitator superfamily (MFS) antibiotic efflux pump	fluoroquinolone antibiotic	antibiotic efflux
mdtE	3000795	protein homolog model	Resistomes & Variants	2	97.66 - 100.0	YES	NO	Escherichia coli; Escherichia marmotae	8.00	0.00	8.00	25.78	336.50	180.17	0	0	0	0	N/A	N/A		1158; 1455	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic; fluoroquinolone antibiotic; penam	antibiotic efflux
EC-8	3006881	protein homolog model	Resistomes & Variants	16	97.35 - 99.73	YES	NO	Escherichia coli	510.00	0.00	510.00	39.20	464.38	199.30	0	0	0	0	N/A	N/A		1134; 1134; 1134; 1134; 1188; 1134; 1134; 1134; 1557; 1158; 1134; 1551; 1167; 1134; 1134; 1134	EC beta-lactamase	cephalosporin	antibiotic inactivation
evgS	3000833	protein homolog model	Resistomes & Variants	27	96.57 - 99.92	YES	NO	Escherichia coli; Shigella boydii	2270.00	0.00	2270.00	13.50	485.33	199.00	0	0	0	0	N/A	N/A		3594; 3594; 3594; 3594; 3594; 3594; 3594; 3594; 3594; 3594; 3618; 3594; 3594; 3594; 3594; 3594; 3594; 3594; 3594; 3594; 3594; 3594; 3594; 3594; 3594; 3642; 3594	major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic	antibiotic efflux
qacJ	3007014	protein homolog model	Resistomes & Variants	1	40.66	NO	NO	Escherichia coli	27.00	0.00	27.00	53.21	166.00	139.74	0	0	0	0	N/A	N/A		312	small multidrug resistance (SMR) antibiotic efflux pump	disinfecting agents and antiseptics	antibiotic efflux
mdtF	3000796	protein homolog model	Resistomes & Variants	3	99.23 - 99.81	YES	NO	Escherichia coli	141.00	0.00	141.00	38.55	1200.33	199.80	0	0	0	0	N/A	N/A		3114; 3114; 3114	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic; fluoroquinolone antibiotic; penam	antibiotic efflux
EC-5	3006880	protein homolog model	Resistomes & Variants	7	98.41 - 100.0	YES	NO	Escherichia coli	328.00	0.00	328.00	17.81	239.86	187.24	0	0	0	0	N/A	N/A		1134; 1557; 1212; 1191; 1557; 1422; 1416	EC beta-lactamase	cephalosporin	antibiotic inactivation
EC-15	3006876	protein homolog model	Resistomes & Variants	2	98.14	YES	NO	Escherichia coli	9.00	0.00	9.00	20.95	237.50	198.64	0	0	0	0	N/A	N/A		1134; 1134	EC beta-lactamase	cephalosporin	antibiotic inactivation
Klebsiella pneumoniae KpnH	3004597	protein homolog model	Resistomes & Variants	7	78.75 - 99.78	YES	NO	Escherichia coli; Morganella morganii; Klebsiella oxytoca; Serratia liquefaciens	100.00	0.00	100.00	24.39	368.29	181.84	0	0	0	0	N/A	N/A		1230; 1404; 1545; 1533; 1539; 1548; 1536	major facilitator superfamily (MFS) antibiotic efflux pump	macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem	antibiotic efflux
gadX	3000508	protein homolog model	Resistomes & Variants	3	93.07 - 99.15	NO	NO	Escherichia coli; Shigella sonnei	314.00	0.00	314.00	18.34	162.33	156.45	0	0	0	0	N/A	N/A		855; 984; 822	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic; fluoroquinolone antibiotic; penam	antibiotic efflux
YojI	3003952	protein homolog model	Resistomes & Variants	1	98.9	YES	NO	Escherichia coli	2.00	0.00	2.00	10.89	179.00	200.50	0	0	0	0	N/A	N/A		1644	ATP-binding cassette (ABC) antibiotic efflux pump	peptide antibiotic	antibiotic efflux
Escherichia coli emrE	3004039	protein homolog model	Resistomes & Variants	9	98.08 - 99.09	NO	NO	Escherichia coli	178.00	0.00	178.00	58.49	228.33	185.91	0	0	0	0	N/A	N/A		306; 333; 333; 339; 504; 351; 423; 573; 339	small multidrug resistance (SMR) antibiotic efflux pump	macrolide antibiotic	antibiotic efflux
AcrS	3000656	protein homolog model	Resistomes & Variants	1	90.45	YES	NO	Escherichia coli; Escherichia marmotae	1.00	0.00	1.00	4.22	28.00	118.00	0	0	0	0	N/A	N/A		663	resistance-nodulation-cell division (RND) antibiotic efflux pump	fluoroquinolone antibiotic; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics	antibiotic efflux
tet(A)	3000165	protein homolog model	Resistomes & Variants	2	97.8 - 100.0	NO	YES	Escherichia coli; Klebsiella pneumoniae	20.00	0.00	20.00	40.12	618.50	189.36	0	0	0	0	N/A	N/A		1614; 1293	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux
EC-18	3006878	protein homolog model	Resistomes & Variants	1	98.9	NO	NO	Escherichia coli	20.00	0.00	20.00	15.87	190.00	186.30	0	0	0	0	N/A	N/A		1197	EC beta-lactamase	cephalosporin	antibiotic inactivation
tet(M)	3000186	protein homolog model	Resistomes & Variants	4	97.03 - 98.44	YES	NO	Escherichia coli; Streptococcus pneumoniae	51.00	0.00	51.00	29.04	551.25	156.15	0	0	0	0	N/A	N/A		774; 1920; 1920; 1920	tetracycline-resistant ribosomal protection protein	tetracycline antibiotic	antibiotic target protection
qacL	3005098	protein homolog model	Resistomes & Variants	1	92.93	NO	NO	Escherichia coli	23.00	0.00	23.00	43.98	157.00	156.61	0	0	0	0	N/A	N/A		357	small multidrug resistance (SMR) antibiotic efflux pump	disinfecting agents and antiseptics	antibiotic efflux
EC-13	3006874	protein homolog model	Resistomes & Variants	1	98.41	NO	NO	Escherichia coli	2.00	0.00	2.00	26.63	302.00	201.00	0	0	0	0	N/A	N/A		1134	EC beta-lactamase	cephalosporin	antibiotic inactivation
EC-14	3006875	protein homolog model	Resistomes & Variants	1	99.73	NO	NO	Escherichia coli	1.00	0.00	1.00	9.70	151.00	199.00	0	0	0	0	N/A	N/A		1557	EC beta-lactamase	cephalosporin	antibiotic inactivation
DHA-21	3002152	protein homolog model	Resistomes & Variants	1	100.0	NO	NO	Morganella morganii	2.00	0.00	2.00	24.47	279.00	200.00	0	0	0	0	N/A	N/A		1140	DHA beta-lactamase	cephalosporin; cephamycin	antibiotic inactivation
LptD	3005059	protein homolog model	Resistomes & Variants	11	91.56 - 98.44	YES	NO	Klebsiella aerogenes; Klebsiella pneumoniae; Raoultella planticola; Klebsiella oxytoca; Klebsiella michiganensis	541.00	0.00	541.00	26.06	615.27	147.95	0	0	0	0	N/A	N/A		2370; 2370; 2316; 2370; 2367; 2367; 2367; 2370; 2367; 2367; 2367	ATP-binding cassette (ABC) antibiotic efflux pump	carbapenem; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic	antibiotic efflux
Klebsiella pneumoniae OmpK37	3004122	protein homolog model	Resistomes & Variants	6	93.05 - 99.47	YES	NO	Klebsiella pneumoniae; Klebsiella quasipneumoniae	143.00	0.00	143.00	27.75	313.00	127.75	0	0	0	0	N/A	N/A		1125; 1155; 1125; 1125; 1125; 1125	General Bacterial Porin with reduced permeability to beta-lactams	monobactam; carbapenem; cephalosporin; cephamycin; penam; penem	reduced permeability to antibiotic
Klebsiella pneumoniae KpnG	3004588	protein homolog model	Resistomes & Variants	2	95.9 - 99.74	YES	NO	Klebsiella pneumoniae; Klebsiella oxytoca	25.00	0.00	25.00	48.35	567.50	159.08	0	0	0	0	N/A	N/A		1194; 1173	major facilitator superfamily (MFS) antibiotic efflux pump	macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem	antibiotic efflux
TEM-1	3000873	protein homolog model	Resistomes & Variants	1	100.0	NO	NO	Klebsiella pneumoniae	7.00	0.00	7.00	12.90	125.00	183.14	0	0	0	0	N/A	N/A		969	TEM beta-lactamase	monobactam; cephalosporin; penam; penem	antibiotic inactivation
MdtK	3001327	protein homolog model	Resistomes & Variants	2	99.37 - 99.79	NO	NO	Salmonella enterica	146.00	0.00	146.00	21.35	380.00	134.65	0	0	0	0	N/A	N/A		1425; 1896	multidrug and toxic compound extrusion (MATE) transporter	fluoroquinolone antibiotic	antibiotic efflux
kdpE	3003841	protein homolog model	Resistomes & Variants	1	91.74	NO	NO	Salmonella enterica	1.00	0.00	1.00	16.89	150.00	3.00	0	0	0	0	N/A	N/A		888	kdpDE	aminoglycoside antibiotic	antibiotic efflux
tet(X4)	3004720	protein homolog model	Resistomes & Variants	1	95.79	NO	NO	Riemerella anatipestifer	1.00	0.00	1.00	12.92	150.00	200.00	0	0	0	0	N/A	N/A		1161	tetracycline inactivation enzyme	glycylcycline; tetracycline antibiotic	antibiotic inactivation
tet(X5)	3005057	protein homolog model	Resistomes & Variants	1	95.88	NO	NO	Riemerella anatipestifer	1.00	0.00	1.00	12.85	150.00	197.00	0	0	0	0	N/A	N/A		1167	tetracycline inactivation enzyme	tetracycline antibiotic	antibiotic inactivation
OXY-2-12	3002407	protein homolog model	Resistomes & Variants	1	100.0	YES	NO	Klebsiella oxytoca	14.00	0.00	14.00	90.72	792.00	194.43	0	0	0	0	N/A	N/A		873	OXY beta-lactamase	monobactam; cephalosporin; penam	antibiotic inactivation
oqxA	3003922	protein homolog model	Resistomes & Variants	1	90.54	YES	NO	Klebsiella oxytoca	8.00	0.00	8.00	51.79	609.00	199.88	0	0	0	0	N/A	N/A		1176	resistance-nodulation-cell division (RND) antibiotic efflux pump	fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic	antibiotic efflux
poxtA	3004470	protein homolog model	Resistomes & Variants	1	66.6	NO	NO	Enterocloster clostridioformis	2.00	0.00	2.00	15.87	258.00	194.00	0	0	0	0	N/A	N/A		1626	Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins	tetracycline antibiotic; oxazolidinone antibiotic; phenicol antibiotic	antibiotic target protection
msrC	3002819	protein homolog model	Resistomes & Variants	1	100.0	NO	NO	Enterococcus faecium	2.00	0.00	2.00	14.94	221.00	185.50	0	0	0	0	N/A	N/A		1479	msr-type ABC-F protein	macrolide antibiotic; streptogramin antibiotic; streptogramin B antibiotic	antibiotic target protection
vanW gene in vanB cluster	3002964	protein homolog model	Resistomes & Variants	1	93.16	YES	NO	Enterococcus faecium	4.00	0.00	4.00	65.45	375.00	200.50	0	0	0	0	N/A	N/A		573	vanW; glycopeptide resistance gene cluster	glycopeptide antibiotic	antibiotic target alteration
CblA-1	3002999	protein homolog model	Resistomes & Variants	1	100.0	NO	NO	Phocaeicola dorei	4150.00	0.00	4150.00	100.00	891.00	193.12	0	0	0	0	N/A	N/A		891	CblA beta-lactamase	cephalosporin	antibiotic inactivation
ArnT	3005053	protein homolog model	Resistomes & Variants	1	63.8	NO	NO	Shigella boydii	67.00	0.00	67.00	9.88	168.00	132.54	0	0	0	0	N/A	N/A		1701	pmr phosphoethanolamine transferase	peptide antibiotic	antibiotic target alteration
norA	3000391	protein homolog model	Resistomes & Variants	1	100.0	YES	NO	Staphylococcus epidermidis	2.00	0.00	2.00	23.80	277.00	199.50	0	0	0	0	N/A	N/A		1164	major facilitator superfamily (MFS) antibiotic efflux pump	fluoroquinolone antibiotic; disinfecting agents and antiseptics	antibiotic efflux
tet(O/W/32/O)	3007122	protein homolog model	Resistomes & Variants	3	97.97 - 98.28	NO	NO	Streptococcus suis	7.00	0.00	7.00	11.20	215.00	198.00	0	0	0	0	N/A	N/A		1920; 1920; 1920	tetracycline-resistant ribosomal protection protein	tetracycline antibiotic	antibiotic target protection
lnuB	3002836	protein homolog model	Resistomes & Variants	1	98.5	YES	NO	Streptococcus suis	2.00	0.00	2.00	37.44	301.00	200.50	0	0	0	0	N/A	N/A		804	lincosamide nucleotidyltransferase (LNU)	lincosamide antibiotic	antibiotic inactivation
tet(45)	3003196	protein homolog model	Resistomes & Variants	1	76.35	YES	NO	Streptococcus suis	2.00	0.00	2.00	16.16	300.00	200.00	0	0	0	0	N/A	N/A		1857	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux
dfrE	3002875	protein homolog model	Resistomes & Variants	1	98.17	YES	NO	Enterococcus faecalis	2.00	0.00	2.00	35.15	174.00	182.00	0	0	0	0	N/A	N/A		495	trimethoprim resistant dihydrofolate reductase dfr	diaminopyrimidine antibiotic	antibiotic target replacement
lsaA	3000300	protein homolog model	Resistomes & Variants	1	100.0	YES	NO	Enterococcus faecalis	6.00	0.00	6.00	42.35	634.00	198.83	0	0	0	0	N/A	N/A		1497	lsa-type ABC-F protein	lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic; pleuromutilin antibiotic	antibiotic target protection
ANT(6)-Ia	3002626	protein homolog model	Resistomes & Variants	1	99.41	NO	NO	Enterococcus faecalis	3.00	0.00	3.00	24.79	177.00	148.33	0	0	0	0	N/A	N/A		714	ANT(6)	aminoglycoside antibiotic	antibiotic inactivation
